Biomarkers in lung cancer screening: achievements, promises and challenges.
Seijo LM, Peled N, Ajona D,
Boeri M, Field JK, Sozzi G, Pio R, Zulueta JJ, Spira A, Massion PP, Mazzone PJ, Montuenga LM.
J Thorac Oncol. 2018 Dec 4. pii: S1556-0864(18)33501-9. doi: 10.1016/j.jtho.2018.11.023. Review.

2018

Circulating mir-320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk.
Fortunato O, Borzi C, Milione M, Centonze G, Conte D, Boeri M, Verri C, Moro M, Facchinetti F, Andriani F, Roz L, Caleca L, Huber V, Cova A, Camisaschi C, Castelli C, Cancila V, Tripodo C, Pastorino U, Sozzi G.
Int J Cancer. 2018 Nov 13. doi: 10.1002/ijc.31988

2018

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.
Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G.
Proc Natl Acad Sci U S A.
2018 Oct 31. pii: 201808314.
doi: 10.1073/pnas.1808314115

2018

Effect of Tobacco Smoking Cessation on C-Reactive Protein Levels in A Cohort of Low-Dose Computed Tomography Screening Participants.
Gallus S, Lugo A, Suatoni P, Taverna F, Bertocchi E, Boffi R, Marchiano A, Morelli D,
Pastorino U.
Sci Rep. 2018 Aug 27;
8(1):12908. doi: 10.1038/s41598-018-29867-9.

2018

Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer
Andriani F, Landoni E, Mensah M, Facchinetti F, Miceli R, Tagliabue E, Giussani M, Callari M, De Cecco L, Colombo MP, Roz L, Pastorino U, Sozzi G
BMC Cancer. 2018
Sep 18;18(1):899.
doi: 10.1186/s12885-018-4772-0.

2018

Mechanisms of tumor immunotherapy, with a focus on thoracic cancers
Ferro S, Huber V, Rivoltini L
J Thorac Dis. 2018
Jul;10(7):4619-4631.
doi: 10.21037/jtd.2018.07.30.

2018

MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1 and MEK1-dependent manner
Andriani F, Majorini MT, Mano M, Landoni E, Miceli R, Facchinetti F, Mensah M, Fontanella E, Dugo M, Giacca M, Pastorino U, Sozzi G, Delia D, Roz L, Lecis D
Journal of Hematology &
Oncology (2018) 11:45

2018

Towards automatic pulmonary nodule management in lung cancer screening with deep learning.
Ciompi F, Chung K, van Riel SJ, Setio AAA, Gerke PK, Jacobs C, Scholten ET, Schaefer-Prokop C, Wille MMW, Marchianò A, Pastorino U, Prokop M,
van Ginneken B.
Sci Rep. 2017 Apr 19;7:46479.
doi: 10.1038/srep46479.
Erratum in: Sci Rep. 2017 Sep 07;7:46878.

2017

Baseline and postoperative
C-reactive protein levels predict mortality in operable lung cancer. Pastorino U, Morelli D, Leuzzi G, Gisabella M, Suatoni P, Taverna F, Bertocchi E, Boeri M, Sozzi G, Cantarutti A, Corrao G.
Eur J Cancer. 2017 Jul;79:90-97. doi: 10.1016/j.ejca.2017.03.020. Epub 2017 May 1.

2017

Inflammatory status and lung function predict mortality in lung cancer screeing participants
Pastorino U, Morelli D, Marchianò A, Sestini S, Suatoni P, taverna F, Boeri M, Sozzi G, Cantarutti A and Corrao G
Eur J Cancer Prev. 2017 Mar 23.
doi: 10.1097/
CEJ.0000000000000342.

2017

Mutational Profile from Targeted NGS Predicts Survival in LDCT Screening-Detected Lung Cancers
Verri C, Borzi C, Holscher T, Dugo M, Devecchi A, Drake K, Sestini S, Suatoni P, Romeo E, Sozzi G, Pastorino U, Boeri M
J Thorac Oncol. 2017 Jun;12(6):922-931. doi: 10.1016/j.jtho.2017.03.001.
Epub 2017 Mar 14.

2017

mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis.
Borzi C, Calzolari L, Centonze G, Milione M, Sozzi G, Fortunato O.
Int J Mol Sci. 2017 Jan 23;18(1). pii: E222. doi: 10.3390/ijms18010222.

2017

Metabolic Evaluation of Non-Small Cell Lung Cancer Patient-Derived Xenograft Models Using 18F-FDG PET: A Potential Tool for Early Therapy Response.
Valtorta S, Moro M, Prisinzano G, Bertolini G, Tortoreto M, Raccagni I, Pastorino U, Roz L, Sozzi G, Moresco RM.
J Nucl Med. 2017 Jan;58(1):42-47. doi: 10.2967/jnumed.116.176404. Epub 2016 Oct 20.

2017

Lung cancer screening with low-dose spiral computed tomography: evidence from a pooled analysis of two Italian randomized trials.
Infante M, Sestini , Galeone C, Marchianò A, Lutman FR, Angeli E, Calareso G, Pelosi G, Sozzi G, Silva M, Sverzellati N, Cavuto S,
La Vecchia C, Santoro A, Alloisio M, Pastorino U.
Eur J Cancer Prev.
2017 Jul;26(4):324-329.
doi: 10.1097/
CEJ.0000000000000264.

2017

Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung.
Lugo R, Gabasa M, Andriani F, Puig M, Facchinetti F, Ramírez J, Gómez-Caro A, Pastorino U, Fuster G, Almendros I, Gascón P, Davalos A, Reguart N, Roz L, Alcaraz J.
Oncotarget. 2016 Dec 13;7(50):82324-82337. doi: 10.18632/oncotarget.10327.

2016

MicroRNA Profile of Lung Tumor Tissues Is Associated with a High Risk Plasma miRNA Signature.
Fortunato O, Verri C, Pastorino U, Sozzi G, Boeri M.
Microarrays (Basel). 2016 Jul 5;5(3). pii: E18. doi: 10.3390/microarrays5030018.

2016

Stopping Smoking Reduces Mortality in Low-Dose Computed Tomography Screening Participants
Pastorino U, Boffi R, Marchianò A, Sestini S, Munarini E, Calareso G, Boeri M, Pelosi G, Sozzi G, Silva M, Sverzellati N, Galeone C, La Vecchia C, Ghirardi A, Corrao G
J Thorac Oncol. 2016 May;11(5):693-9. doi: 10.1016/j.jtho.2016.02.011.
Epub 2016 Feb 24.

2016

Low-dose computed tomography for lung cancer screening: comparison of performance between annual and biennial screen.
Sverzellati N, Silva M, Calareso G, Galeone C, Marchianò A, Sestini S, Sozzi G, Pastorino U.
Eur Radiol. 2016 Nov;26(11):3821-3829.
Epub 2016 Feb 11. doi: 10.1007/s00330-016-4228-3

2016

Screening with Low-Dose Computed Tomography Does Not Improve Survival of Small Cell Lung Cancer.
Silva M, Galeone C, Sverzellati N, Marchianò A, Calareso G, Sestini S, La Vecchia C, Sozzi G, Pelosi G, Pastorino U.
J Thorac Oncol. 2016 Feb;11(2):187-93. doi: 10.1016/j.jtho.2015.10.014.
Epub 2015 Dec 23.

2016

Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells.
Andriani F, Bertolini G, Facchinetti F, Baldoli E, Moro M, Casalini P, Caserini R, Milione M, Leone G, Pelosi G, Pastorino U, Sozzi G,
Roz L.
Mol Oncol. 2016 Feb;10(2):253-71. doi: 10.1016/j.molonc.2015.10.002.
Epub 2015 Oct 22.

2016

Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma.
Pintarelli G, Dassano A, Cotroneo CE, Galvan A, Noci S, Piazza R, Pirola A, Spinelli R, Incarbone M, Palleschi A, Rosso L, Santambrogio L, Dragani TA, Colombo F.
Oncotarget. 2016 May 10;7(19):27889-98. doi: 10.18632/oncotarget.8556.

2016

Novel method to detect microRNAs using chip-based QuantStudio 3D digital PCR.
Conte D, Verri C, Borzi C, Suatoni P, Pastorino U, Sozzi G,
Fortunato O.
BMC Genomics. 2015 Oct 23;16:849. doi: 10.1186/s12864-015-2097-9.

2015

Complexity in the tumour microenvironment: Cancer associated fibroblast gene expression patterns identify both common and unique features of tumour-stroma crosstalk across cancer types.
Gandellini P, Andriani F, Merlino G, D'Aiuto F, Roz L, Callari M
Semin Cancer Biol. 2015 Dec;35:96-106. doi: 10.1016/j.semcancer.2015.08.008.
Epub 2015 Aug 28

2015

Germline polymorphisms and survival of lung adenocarcinoma patients: A genome-wide study in two European patient series.
Galvan A, Colombo F, Frullanti E, Dassano A, Noci S, Wang Y, Eisen T, Matakidou A, Tomasello L, Vezzalini M, Sorio C, Dugo M, Ambrogi F, Iacobucci I, Martinelli G, Incarbone M, Alloisio M, Nosotti M, Tosi D, Santambrogio L, Pelosi G, Pastorino U, Houlston RS, Dragani TA
Int J Cancer.
2015 Mar 1;136(5):E262-71.
doi: 10.1002/ijc.29195.
Epub 2014 Sep 19

2015

Recent advances of microRNA-based molecular diagnostics to reduce false-positive lung cancer imaging.
Boeri M, Sestini S, Fortunato O, Verri C, Suatoni P, Pastorino U, Sozzi G
Expert Rev Mol Diagn. 2015 Jun;15(6):801-13. doi: 10.1586/14737159.2015.1041377. Epub 2015 Apr 30.

2015

Microenvironment modulated
metastatic CD133+/CXCR4+/
EpCAM- lung cancer initiating
cells sustain tumor dissemination
and correlate with poor prognosis.
Bertolini G, D'Amico L, Moro M, Landoni E, Perego P, Miceli R, Gatti L, Andriani F, Wong D, Caserini R, Tortoreto M,
Milione M, Ferracini R,
Mariani L, Pastorino U, Roato I, Sozzi G, Roz L
Cancer Res. 2015 Sep 1;75(17):3636-49. doi: 10.1158/0008-5472.CAN-14-3781. Epub 2015 Jul 3.

2015

Gene Signatures Stratify Computed Tomography Screening Detected Lung Cancer in High-Risk Populations.
Hu J, Boeri M, Sozzi G, Liu D, Marchianò A, Roz L, Pelosi G, Gatter K, Pastorino U, Pezzella F
EBioMedicine. 2015 Jul 8;2(8):831-40. doi: 10.1016/j.ebiom.2015.07.001. eCollection 2015 Aug.

2015

Circulating microRNA signature as liquid-biopsy to monitor lung cancer in low-dose computed tomography screening.
Sestini S, Boeri M, Marchiano A, Pelosi G, Galeone C, Verri C, Suatoni P, Sverzellati N, La Vecchia C, Sozzi G, Pastorino U
Oncotarget. 2015 Oct 20;6(32):32868-77. doi: 10.18632/oncotarget.5210.

2015

Oligogenic germline mutations identified in early non-smokers lung adenocarcinoma patients.
Renieri A, Mencarelli MA, Cetta F, Baldassarri M, Mari F, Furini S, Piu P, Ariani F, Dragani TA, Frullanti E.
Lung Cancer. 2014 Aug;85(2):168-74. doi: 10.1016/j.lungcan.2014.05.020.
Epub 2014 Jun 4.

2014

Assessment of circulating microRNAs in plasma of lung cancer patients.
Fortunato O, Boeri M, Verri C, Conte D, Mensah M, Suatoni P, Pastorino U, Sozzi G
Molecules. 2014 Mar 10;19(3):3038-54. doi: 10.3390/molecules19033038.

2014

Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study.
Sozzi G, Boeri M, Rossi M, Verri C, Suatoni P, Bravi F, Roz L, Conte D, Grassi M, Sverzellati N, Marchiano A, Negri E, La Vecchia C,
Pastorino U
J Clin Oncol. 2014 Mar 10;32(8):768-73. doi: 10.1200/JCO.2013.50.4357.
Epub 2014 Jan 13.

2014

Therapeutic Use of MicroRNAs in Lung Cancer.
Fortunato O, Boeri M, Verri C, Moro M, Sozzi G
Biomed Res Int. 2014;2014:756975. doi: 10.1155/2014/756975.
Epub 2014 Sep 16

2014

Potential biomarkers for lung cancer screening.
Sozzi G, Boeri M
Transl Lung Cancer Res.
2014 Jun;3(3):139-48.
doi: 10.3978/j.issn.2218-
6751.2014.06.04.

2014

Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction.
Fortunato O, Boeri M, Moro M, Verri C, Mensah M, Conte D, Caleca L, Roz L, Pastorino U,
Sozzi G
Cell Death Dis.
2014 Dec 11;5:e1564.
doi: 10.1038/cddis.2014.507.

2014

Gene expression signature of non-involved lung tissue associated with survival in lung adenocarcinoma patients. 
Galvan A, Frullanti E, Anderlini M, Manenti G, Noci S, Dugo M, Ambrogi F, De Cecco L, Spinelli R, Piazza R, Pirola A, Gambacorti-Passerini C, Incarbone M, Alloisio M, Tosi D, Nosotti M, Santambrogio L, Pastorino U, Dragani TA. 
Carcinogenesis.
2013 Dec;34(12):2767-73.
doi: 10.1093/carcin/bgt294.
Epub 2013 Aug 25

2013

Multiple isoforms and differential allelic expression of CHRNA5 in lung tissue and lung adenocarcinoma. 
Falvella FS, Alberio T, Noci S, Santambrogio L, Nosotti M, Incarbone M, Pastorino U,
Fasano M, Dragani TA. 
Carcinogenesis.
2013 Jun;34(6):1281-5.
doi: 10.1093/carcin/bgt062.
Epub 2013 Feb 19.

2013

Adipose tissue displays trophic properties on normal lung cellular components without promoting cancer cells growth.
Andriani F, Facchinetti F, Furia S, Roz L, Bursomanno S, Bertolini G, Carniti C, Sozzi G, Pastorino U.
J Cell Physiol.
2013 Jun;228(6):1166-73.
doi: 10.1002/jcp.24270.

2013

Role of microRNAs in lung cancer: microRNA signatures in cancer prognosis. 
Boeri M, Pastorino U, Sozzi G.
Cancer J.
2012 May-Jun;18(3):268-74.
doi: 10.1097/
PPO.0b013e318258b743

2012

Copyright © 2017 INT

Fondazione IRCCS Istituto Nazionale dei Tumori

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Copyright © 2017 INT

Fondazione IRCCS Istituto Nazionale dei Tumori

Tutti i diritti sono riservati

website by Studio Luvié

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Copyright © 2017 INT

Fondazione IRCCS Istituto Nazionale dei Tumori

Tutti i diritti sono riservati

website by Studio Luvié